一、个人简介

博士，教授，博士生导师，国务院特殊津贴专家，四川省学术和技术带头人，四川省中医药学术和技术带头人，四川省有突出贡献优秀专家。长期从事中药化学成分与中药质量标准化研究，探索和阐明中药药效物质基础，重点围绕川产道地药材附子、川乌、石斛、熊胆粉等品种的化学成分、炮制、配伍、药理活性等多方面研究，对建立其质量控制体系进行了积极探索。研发新药及健康产品10余项，主持多项科研课题，授权专利10余项，出版专著20余部，发表论文百余篇，其中SCI论文50余篇，包括《Biomaterials》、《European Journal of Medicinal Chemistry》、《Phytochemical Analysis》、《Chemical Record》等著名期刊；培养硕博研究生50余名。

二、代表性成果（可含承担项目、发表论文、论著、获奖等）

一）项目

1. 国家科技部，国家重点研发项目子课题，2017YFC1701804，高品质道地药材中药材附子规模化种植及精准扶贫示范研究，2018.01-2021-12, 37.5万元，结题，主持

2. 四川省科技厅，四川省科技基础条件平台项目，2019JDPT0032，四川省中药化合物资源共享平台，2019.01-2021.12, 12.5万元，结题，主持

3. 国家自然科学基金，区域创新发展联合基金，U19A2010，川产道地药材的道地性研究，2020.01-2023.12, 247万元，在研，主研

4. 横向课题，熊胆、梅花鹿系列产品研究开发，成都晶博生物科技有限责任公司，2020.07-2022.07, 120万元，在研，主持

二）论文

1. Xiao Haijun^#; Guo Yiping^#; Liu Hongmei; Liu Yushi; Wang Yumin; Li Changqing; Jaroslav Císař; David Škoda; Ivo Kuřitka; Guo Li^*; Vladimír Sedlaříkp^*; Structure-based design of charge-conversional drug self-delivery systems for better targeted cancer therapy, Biomaterials, 2020, 232.

2. Li He^#; Qian Su^#; Lan Bai^#; Meifeng Li; Juanru Liu; Xiaomei Liu; Cunyan Zhang; Zhongliang Jiang; Jun He; Jianyou Shi^*; Shan Huang^*; Li Guo^*; Recent research progress on natural small molecule bibenzyls and its derivatives in Dendrobium species, European Journal of Medicinal Chemistry, 2020, 112530.

3. Zhang Zhen^##; Jiang Maoyuan^#; Wei Xinyi; Shi Jingfeng; Geng Zhao; Yang Shasah; Fu Chaomei^*; Guo Li^*; Rapid discovery of chemical constituents and absorbed components in rat serum after oral administration of Fuzi-Lizhong pill based on high-throughput HPLC-Q-TOF/MS analysis, Chinese Medcine, 2019, 14(6): 1-22.

4. Liu Hongmei; Fang Chengxin; Zhang Tingmo; Guo Li^*; Ye Qiang^*; Molecular authentication and differentiation of Dendrobium species by rDNA ITS region sequence analysis, AMB Express, 2019, 9(53): 1-9

5. Ye Qiang; Liu Hongmei; Fang Chengxin; Liu Yushi; Liu Xiaomei; Liu Juanru; Zhang Cunyan; Zhang Tingmo; Peng Cheng^*; Guo Li^*; Cardiotoxicity evaluation and comparison of diterpene alkaloids on zebrafish, Drug and Chemical Toxicology, 2019: 1-8.

6. Zhang Xiao; Zou, Lihua; He Yulin; Peng Cheng; Guo Li^*; Xiong Liang^*. Triterpenoid saponins from the buds of Lonicera similis. Natural Product Research, 2018, 32: 2282-2290.

7. Liu YS, Yuan MH, Zhang CY, Liu HM, Liu JR, Wei AL, Ye Q, Zeng B, Li MF, Guo YP, Guo L*. Puerariae Lobatae radix flavonoids and puerarin alleviate alcoholic liver injury in zebrafish by regulating alcohol and lipid metabolism. Biomed Pharmacother. 2021; 134:111121.

8. Liu H, Yuan M, Liu Y, Guo Y, Xiao H, Guo L*, Liu F. Self-Monitoring and Self-Delivery of Self-Assembled Fluorescent Nanoparticles in Cancer Therapy. Int J Nanomedicine. 2021; 16:2487-99.

9. Guo Y, Liu H, Xiao H, Yuan M, Liu Y, Sedlarik V, Chin WC, Liu J, Guo L*, Li C. Self-assembled Camptothecin derivatives - Curcuminoids conjugate for combinatorial chemo-photodynamic therapy to enhance anti-tumor efficacy. J Photochem Photobiol B. 2021; 215:112124.

10. Lei K, Yuan M, Zhou T, Ye Q, Zeng B, Zhou Q, Wei A, Guo L*. Research progress in the application of bile acid-drug conjugates: A "trojan horse" strategy. Steroids. 2021; 173:108879.

三）获奖

1. 郭力，参附注射液品质控制与产业化关键技术应用，国家科技部，国家科学技术进步奖，二等奖，2013

2. 郭力，乌头类有毒中药安全性评价模式的建立与示范，中国医疗保健国际交流促进会，华夏医学科技奖，二等奖，2013

3. 郭力，参附注射液的基础、临床与产业化关键问题研究，四川省人民政府，四川省科技进步奖，一等奖，2012

4. 郭力，附子的系统研究与开发应用，四川省人民政府，四川省科技进步奖，一等奖，2010

5. 郭力，病证结合动物模型创制与中药复方有效部位创新中药寻找模式研究，四川省人民政府，四川省科技进步奖，一等奖，2006