詹固
一、个人简介
詹固博士，副教授，四川省特聘专家，威尼斯98488高层次引进人才。2007-2016年于四川大学华西药学院学习并获得理学博士学位。同年赴美国纽约州立大学进行博士后研究，研究多肽的选择性化学合成。随后加入日本国立理化学研究所进行博士后研究，师从著名化学家侯召民教授。相关科研成果发表在Chem. Soc. Rev., Angew. Chem. Int. Ed., J. Am. Chem. Soc., Chem. Sci., Acs Catal.等国际顶级学术期刊上，并获“2018年日本国立理化学研究所研究奖励奖”、“2019年日本国立理化学研究所理事长感谢状”、“2019年英国皇家化学会OBC壁报奖”、“2023年四川省医学科技奖一等奖”等奖项。
目前的主要研究方向为中药相关重要手性化合物的不对称催化、绿色合成及方法开发、结构改造、“构-效-毒”多维关系评价及创新药物研发。旨在结合中药化学、有机化学、催化、生物学的前沿技术手段研究中药药效物质基础的基本科学问题。任学术期刊《Frontiers in catalysis》副主编、《Frontiers in chemistry》杂志客座编辑、《泰国中医药杂志》编委、科学出版社教材《有机化学》副主编。2020年加入威尼斯98488药学院以来，已主持国家自然科学基金面上项目 (22371021)、青年项目 (22001024)、四川省千人计划青年项目、四川省自然科学基金面上项目、四川省科技厅应用基础研究项目 (2021YJ0402)、威尼斯98488“杏林学者”科研提升、引进人才项目等。
二、个人代表性成果
[1] Q.Q. Yang, C. Chen, D.H. Yao, W. Liu, B. Liu*, J. Zhou, D. B. Pan, C. Peng, G. Zhan*, B. Han*, Catalytic Atroposelective Synthesis of Axially Chiral Azomethine Imines and Neuroprotective Activity Evaluation, Angew. Chem. Int. Ed., 136 (2024). (中科院一区，IF:16.6)
[2] C. Chen, J. Zhou, J. Jiang, Y. Li, T. Mao, C. Peng, G. Zhan*, W. Huang*, Remote stereocontrol in the (4 + 2) cycloadditions of 1,7-zwitterions: Asymmetric synthesis of multifunctionalized tetrahydroquinoline derivatives, Chinese Chem. Lett., 35 (2024) 108295. (中科院一区，IF:9.1)
[3] J. Wang, T. Qi, S.R. He, W. Huang, C. Peng, G. Zhan*, B. Han*, Catalyst-Controlled Switchable (5 + 4)/(3 + 4) Cycloadditions for the Divergent Synthesis of Pyrazole-Fused Seven- and Nine-Membered Heterocycles, ACS Catal., 13 (2023) 10694-10704. (中科院一区，IF:12.9)
[4] Y.D. Niu, L.P. Yao, H.L. Zhao, X. Tang, Q. Zhao*, Y.L. Wu, B. Han, W. Huang*, G. Zhan*, Construction of Cyclopentanes Consisting of Five Stereocenters via NHC-Catalyzed Cascade Reactions of Enals with Oxindole-Dienones, Org. Lett., 25 (2023) 8445-8450. (中科院一区，IF:5.2)
[5] Y.L. Wu, W.J. Zhou, L.P. Yao, Y.D. Niu, H.L. Zhao, C. Peng, B. Han, W. Huang*, G. Zhan*, Organocatalytic atroposelective synthesis of naphthoquinone thioglycosides from aryl-naphthoquinones and thiosugars, Chem. Commun., 59 (2023) 7279-7282. (中科院二区，IF:4.9)
[6] H.P. Li, X.L. Wu, G. Zhan*, X.J. Fu, J.H. Chen, X.H. He*, B. Han*, Construction of cyclopenta[b]dihydronaphthofurans via TsOH-catalyzed consecutive biscyclization of dithioallylic alcohols and 1-styrylnaphthols, Chem. Commun., 59 (2023) 2275-2278. (中科院二区，IF:4.9)
[7] H.Y. Fang, Y. Li, L. Zhang*, Z.H. Yan, K. Ma, C. Peng, W. Huang*, G. Zhan*, Chemo- and Diastereoselective Cycloisomerization/[2+3] Cycloaddition of Enynamides: Synthesis of Spiropyrazolines as Potential Anticancer Reagents, J. Org. Chem., (88) 2023 7311-7319. (中科院二区，IF:3.6)
[8] M.L. Luo, Q. Zhao*, X.H. He, X. Xie, H.P. Zhu, F.M. You, C. Peng, G. Zhan*, W. Huang*, Research progress of indole-fused derivatives as allosteric modulators: Opportunities for drug development, Biomed. Pharmacother., 162 (2023) 114574. (中科院二区，IF:7.5)
[9] J. Jiang, J. Zhou, Y. Li, C. Peng, G. He, W. Huang, G. Zhan*, B. Han*, Silver/chiral pyrrolidinopyridine relay catalytic cycloisomerization/(2 + 3) cycloadditions of enynamides to asymmetrically synthesize bispirocyclopentenes as PDE1B inhibitors, Commun. Chem., 6 (2023). (中科院二区，IF:5.9)
[10] R. Qin, F.M. You, Q. Zhao, X. Xie, C. Peng, G. Zhan*, B. Han*, Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets, J. Hematol Oncol., 15 (2022) 133. (中科院一区，IF:28.5)
[11] X.F. Cong, Q.D. Zhuo, N. Hao, Z.B. Mo, G. Zhan, M. Nishiura, Z.M. Hou*, Regio- and Diastereoselective [3+2] Annulation of Aliphatic Aldimines with Alkenes by Scandium-Catalyzed β-C(sp3)-H Activation, Angew. Chem. Int. Ed., 66 (2022). (中科院一区，IF:16.6)
[12] Q.Q. Luo, Z. Tian, J. Tang, J. Wang, Y. Tian*, C. Peng, G. Zhan*, B. Han*, Design and Application of Chiral Bifunctional 4-Pyrrolidinopyridines: Powerful Catalysts for Asymmetric Cycloaddition of Allylic N-Ylide, ACS Catal., 12 (2022) 7221-7232. (中科院一区，IF:12.9)
[13] J. Tang, Z.H. Yan, G. Zhan*, Q.Q. Yang, Y.Y. Cheng, X. Li*, W. Huang*, Visible-light-mediated sequential Wolff rearrangement and Staudinger cycloaddition enabling the assembly of spiro-pyrazolone-beta-lactams, Org. Chem. Front., 9 (2022) 4341-4346. (中科院一区，IF:5.4)
[14] C.H. Li, W.F. Zuo, J. Zhou, W.J. Zhou, M. Wang, X. Li, G. Zhan*, W. Huang*, Catalytic asymmetric synthesis of 3,4 '-indole-pyrazole derivatives featuring axially chiral bis-pentatomic heteroaryls, Org. Chem. Front., 9 (2022) 1808-1813. (中科院一区，IF:5.4)
[15] X.H. He, X.J. Fu, G. Zhan*, N. Zhang, X. Li, H.P. Zhu, C. Peng, G. He*, B. Han*, Organocatalytic asymmetric synthesis of multifunctionalized alpha-carboline-spirooxindole hybrids that suppressed proliferation in colorectal cancer cells, Org. Chem. Front., 9 (2022) 1048-1055. (中科院一区，IF:5.4)
[16] Q.W. Pang, J. Zhou, Y.L. Wu, W.J. Zhou, W.F. Zuo, G. Zhan*, B. Han*, Construction of Oxo-Bridged Diazocines via Rhodium-Catalyzed (4+3) Cycloaddition of Carbonyl Ylides with Azoalkenes, Org. Lett., 24 (2022) 1362-1366. (中科院一区，IF:5.2)
[17] M.L. Luo, Q.M. Hou, S.J. Liu, Q. Zhao, R. Qin, C. Peng, B. Han*, G. Zhan*, One-Step Synthesis of Hydropyrrolo[3,2-b]indoles via Cascade Reactions of Oxindole-Derived Nitrones with Allenoates, Org. Lett., 24 (2022) 8493-8497. (中科院一区，IF:5.2)
[18] D.A. Li, X.H. He, X. Tang, Y.L. Wu, H.L. Zhao, G. He, C. Peng, B. Han*, G. Zhan*, Organo/Silver Dual Catalytic (3+2)/Conia-Ene Type Cyclization: Asymmetric Synthesis of Indane-Fused Spirocyclopenteneoxindoles, Org. Lett., 24 (2022) 6197-6201. (中科院一区，IF:5.2)
[19] Z. Tian, J. Jiang, Z.H. Yan, Q.Q. Luo, G. Zhan*, W. Huang, X. Li*, B. Han*, Catalytic asymmetric [3+2] cycloaddition of pyrazolone-derived MBH carbonate: highly stereoselective construction of the bispiro-[pyrazolone-dihydropyrrole-oxindole] skeleton, Chem. Commun., 58 (2022) 5363-5366. (中科院一区，IF:4.9)
[20] R. Qin, Q. Zhao, B. Han, H.P. Zhu, C. Peng, G. Zhan*, W. Huang*, Indole-Based Small Molecules as Potential Therapeutic Agents for the Treatment of Fibrosis, Front. Pharmacol., 13 (2022). (中科院二区，IF:5.6)
[21] H.J. Leng, Q. Zhao, Q. Mao, S.J. Liu, M.L. Luo, R. Qin, W. Huang*, G. Zhan*, NHC-catalysed retro-aldol/aldol cascade reaction enabling solvent-controlled stereodivergent synthesis of spirooxindoles, Chin. Chem. Lett., 32 (2021) 2567-2571. (中科院一区，IF:9.1)
[22] W.F. Zuo, J. Zhou, Y.L. Wu, H.Y. Fang, X.J. Lang, Y. Li, G. Zhan*, B. Han*, Synthesis of spiro(indoline-2,3 '-hydropyridazine) via an "on-water" [4+2] annulation reaction, Org. Chem. Front., 8 (2021) 922-927. (中科院一区，IF:5.4)
[23] Q. Zhao, C. Peng, Y.-T. Wang, G. Zhan*, B. Han*, Recent progress on the construction of axial chirality through transition-metal-catalyzed benzannulation, Org. Chem. Front., 9 (2021) 2772–2785. (中科院一区，IF:5.4)
[24] X. Tang, Y.L. Wu, J. Jiang, H.Y. Fang, W.J. Zhou, W. Huang*, G. Zhan*, Formal (3+1+1) Carboannulation of Morita-Baylis-Hillman Carbonates with Pyridinium Ylides: Access to Spiro-Cyclopentadiene Oxindoles, Org. Lett., 23 (2021) 8937-8941. (中科院一区，IF:5.2)
[25] Y.Y. Ai, D.A. Li, G. Li, H.P. Li, X.H. He, X.J. Fu, Y.T. Wang, G. Zhan*, B. Han*, Asymmetric Synthesis of Spirocyclopentane Oxindoles via [2+3] Annulation with 2-(2-Oxoindolin-3-yl)malononitriles as 1,2-Carbon Bisnucleophiles, Adv. Synth. Catal., 363 (2021) 3283-3289. (中科院二区，IF:5.4)
[26] X.F. Cong, G. Zhan, Z.B. Mo, M. Nishiura, Z.M. Hou*, Diastereodivergent [3+2] Annulation of Aromatic Aldimines with Alkenes via C-H Activation by Half-Sandwich Rare-Earth Catalysts, J. Am. Chem. Soc., 142 (2020) 5531-5537. (中科院一区，IF:15.0)
[27] X. Tang, N. Zhang, G. He, C.H. Li, W. Huang, X.Y. Wang, G. Zhan*, B. Han*, Unconventional [2+3] Cyclization Involving [1,4]-Sulfonyl Transfer to Construct Polysubstituted Fluorazones as Inhibitors of Indoleamine 2,3-Dioxygenase 1, Org. Lett., 22 (2020) 7909-7914. (中科院一区，IF:5.2)
[28] R. Zhou+, J.S. Li+, H.W. Cheo, R. Chua, G. Zhan, Z.M. Hou, J. Wu*, Visible-light-mediated deuteration of silanes with deuterium oxide, Chem. Sci., 10 (2019) 7340-7344. (中科院一区，IF:8.4)
[29] G. Zhan, H.L. Teng, Y. Luo, S.J. Lou, M. Nishiura, Z.M. Hou*, Enantioselective Construction of Silicon-Stereogenic Silanes by Scandium-Catalyzed Intermolecular Alkene Hydrosilylation, Angew. Chem. Int. Ed., 57 (2018) 12342-12346. (中科院一区，IF:16.6)
[30] Y.H. Ma, S.J. Lou, G. Luo, Y. Luo, G. Zhan, M. Nishiura, Y. Luo, Z.M. Hou*, B(C6F5)3/Amine-Catalyzed C(sp)-H Silylation of Terminal Alkynes with Hydrosilanes: Experimental and Theoretical Studies, Angew. Chem. Int. Ed., 57 (2018) 15222-15226. (中科院一区，IF:16.6)
[31] H.L. Teng, Y.H. Ma, G. Zhan, M. Nishiura, Z.M. Hou*, Asymmetric C(sp)-H Addition of Terminal Alkynes to Cyclopropenes by a Chiral Gadolinium Catalyst, ACS Catal., 8 (2018) 4705-4709. (中科院一区，IF:12.9)
[32] G. Zhan+, W. Du+, Y.C. Chen*, Switchable divergent asymmetric synthesis via organocatalysis, Chem. Soc. Rev., 46 (2017) 1675-1692. (中科院一区，IF:42.6)
[33] W.J. Lin, G. Zhan, M.L. Shi, W. Du*, Y.C. Chen*, [3+3] Formal Cycloadditions of Nitrones from Isatins and Azaoxyallyl Cations for Construction of Spirooxindoles, Chin. J. Chem. 35 (2017) 857-860. (中科院二区，IF:5.4)
[34] G. Zhan, M.L. Shi, W.J. Lin, Q. Ouyang, W. Du*, Y.C. Chen*, Direct Asymmetric Aza-Vinylogous-Type Michael Additions of Nitrones from Isatins to Nitroalkenes, Chem. Eur. J., 23 (2017) 6286-6289. (中科院二区，IF:4.3)
[35] G. Zhan, M.L. Shi, Q. He, W.J. Lin, Q. Ouyang, W. Du, Y.C. Chen*, Catalyst-Controlled Switch in Chemo- and Diastereoselectivities: Annulations of Morita-Baylis-Hillman Carbonates from Isatins, Angew. Chem. Int. Ed., 55 (2016) 2147-2151. (中科院一区，IF:16.6)
[36] M.L. Shi, G. Zhan, S.L. Zhou, W. Du, Y.C. Chen*, Asymmetric Inverse-Electron-Demand Oxa-Diels-Alder Reaction of Allylic Ketones through Dienamine Catalysis, Org. Lett., 18 (2016) 6480-6483. (中科院一区，IF:5.2)
[37] Y.R. Chen, G. Zhan, W. Du*, Y.C. Chen*, Regioselective Asymmetric Formal (3+2) Cycloadditions of Nitrone Ylides from Isatins and Enals, Adv. Synth. Catal., 358 (2016) 3759-3764. (中科院二区，IF:5.4)
[38] G. Zhan, M.L. Shi, Q. He, W. Du, Y.C. Chen*, [4+3] Cycloadditions with Bromo-Substituted Morita-Baylis-Hillman Adducts of Isatins and N-(ortho-Chloromethyl)aryl Amides, Org. Lett., 17 (2015) 4750-4753.IF: (中科院一区，IF:5.2)