一、个人简介

胡川，特聘副研究员，硕士生导师。2012-2022年于四川大学华西药学院药剂学系学习并获得理学博士学位。2023年6月通过高层次人才引进到威尼斯98488药学院工作。在Advanced Functional Materials, Biomaterials, Acta Pharmaceutica Sinica B, Advanced Drug Delivery Reviews等期刊以第一作者发表SCI论文9篇，最高影响因子为19。先后获得“四川省自然科学基金青年项目”、“威尼斯98488引进人才科研启动项目”等资助。

联系方式：huchuan@cdutcm.edu.cn

研究方向：

1. 智能响应性递释系统用于免疫制剂及中药活性分子高效递送的研究

2. 脑部高效递释系统的设计与评价

二、代表性成果

1. Hu Chuan#, Wu Baoyu#, Wu Yihan, Shi Mingyi, Ma Jiaqi, Gao Huile*, Zhang Jinming*. Recent advances in nanotechnology for combating Alzheimer's disease. Mater. Chem. Front., 2023, 7(21): 5171-5186. (IF=7)  

2. Hu Chuan#, Song Yujun#, Zhang Yiwei, He Siqin, Liu Xueying, Yang Xiaotong, Gong Tao, Huang Yuan, Gao Huile*. Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome. Acta Pharm Sin B, 2023, 13(5): 2176-2187. (IF=14.5)  

3. Hu Chuan, Gao Huile*. A cleavable self-delivery nanoparticle for tumor photo-immunotherapy. Asian J Pharm Sci, 2021, 16(4): 133-135. (IF=9.273)  

4. Hu Chuan, He Xueqin, Chen Yuxiu, Yang Xiaotong, Qin Lin, Lei Ting, Zhou Yang, Gong Tao, Huang Yuan, Gao Huile*. Metformin mediated PD-L1 downregulation in combination with photodynamic-immunotherapy for treatment of breast cancer. Adv Funct Mater, 2021, 31(11), 2007149. (IF=19.000)

5. Hu Chuan, Lei Ting, Wang Yazhen, Cao Jun, Yang Xiaotong, Qin Lin, Liu Rui, Zhou Yang, Tong Fan, Umeshappa Sokke Channakeshava*, Gao Huile*. Phagocyte-membrane-coated and laser-responsive nanoparticles control primary and metastatic cancer by inducing anti-tumor immunity. Biomaterials, 2020, 255, 120159. (IF=10.317)

6. Hu Chuan,Cun Xingli, Ruan Shaobo, Liu Rui, Xiao Wei, Yang Xiaotong, Yang Yuanyuan, Yang Chuanyao, Gao Huile*.Enzyme-triggered size shrink and laser-enhanced NO release nanoparticles for deep tumor penetration and combination therapy. Biomaterials, 2018, 168: 64-75. (IF=10.273)

7. Hu Chuan, Yang Xiaotong, Liu Rui, Ruan Shaobo, Zhou Yang, Xiao Wei, Yu Wenqi, Yang Chuanyao, Gao Huile*. Coadministration of iRGD with multistage responsive nanoparticles enhanced tumor targeting and penetration abilities for breast cancer therapy. ACS Appl Mater Inter, 2018, 10(26):22571-22579. (IF=8.456)

8. Hu Chuan#, Liu Yongmei#, Chen Jiantao, He Qin, Gao Huile*. A simple one-step synthesis of melanin-originated red shift emissive carbonaceous dots for bioimaging. JColloid Interf Sci, 2016, 480: 85-90. (IF=5.091)

9. Yu Wenqi#, Hu Chuan#, Gao Huile*. Advances of nanomedicines in breast cancer metastasis treatment targeting different metastatic stages. Adv Drug Deliv Rev, 2021, 178: 113909. (IF= 17.873)

10. Yu Wenqi#, Hu Chuan#, Gao Huile*, Intelligent Size-Changeable Nanoparticles for Enhanced Tumor Accumulation and Deep Penetration. ACS Appl Bio Mater, 2020, 3 (9), 5455-5462.

11. 胡川, 宋钰珺，高会乐*。肿瘤微环境响应性纳米递药系统用于肿瘤免疫治疗的研究进展. 药学进展，2022，46(07): 485-494。

12. 胡川，高会乐*。肿瘤微环境响应性与调节性递药系统研究进展。药学学报(Acta Pharmaceutica Sinica), 2020, 55(7): 1520-1527。

13. Ruan Shaobo, Hu Chuan, Tang Xian, Cun Xingli, Xiao Wei, Shi Kairong, He Qin, Gao Huile*. Increased gold nanoparticle retention in brain tumors by in situ enzyme-induced aggregation. ACS Nano, 2016, 10(11): 10086-10098. (IF=13.709)