一、个人简介

教授、硕士研究生导师、美国休斯敦大学访问学者、博士、博士后。

四川省海外高层次留学人才、四川省学术和技术带头人后备人选、国家自然科学基金委通讯评审专家、教育部学位中心评审专家、成都欧美同学会•成都留学人员联谊会第一届理事会理事、威尼斯98488欧美同学会•留学人员联谊会会员、威尼斯98488优势特色学科中药制剂学学术带头人后备人选。

研究方向：（1）中药新制剂、新剂型研究；（2）口服胃肠道释药系统研究。

2、代表性成果

承担项目：

1. 2021/04-2023/04，基于“香-效”整合作用的木香精油质量标准提升及大健康产品开发研究，四川省科技厅重点研发项目，负责人

2. 2021/12-2023/12，四川省2021-2023年“三区”人才支持计划科技人员专项计划，四川省科技厅，负责人

3. 2019/09-2022/08，黑水县当归全产业链开发应用示范，四川省科技厅重点研发项目，主研

4. 2019/01-2021/12，基于“丸剂特征-整合药动-机体应答”的附子理中丸“去性存用”作用机制研究，国家自然科学基金青年基金，主研

5. 2015/01-2018/12，基于体内分布及机体应答部位差异性的川木香煨制与归经趋向相关性研究，国家自然科学基金面上项目，负责人

6. 2014/01-2017/12，四逆汤药味配伍‘毒减而效不减的机制研究’，国家自然科学基金面上项目，主研

7. 2014/01-2016/12，基于‘组分-药效-靶点’作用网络研究四物汤制备工艺环节评价模式，国家自然科学基金青年基金，主研

8. 2011/01-2013/12，从胃肠吸收及部位差异性角度研究川木香煨制前后功效变化的药动学基础，国家自然科学基金青年基金，负责人

9. 2007/07-2009/07，川木香煨制前后药效成分变化与药理作用相关性研究，四川省科技厅应用基础，负责人

 发表论文、论著、获奖等： 

1. Chunlei Wei, Jing Qiu, Yuyi Wu, Ziqiang Chen, Ziwei Yu, Zecheng Huang, Ke Yang, Huiling Hu* , Fang Liu*. Promising traditional Chinese medicine for the treatment of cholestatic liver disease process (cholestasis, hepatitis, liver fibrosis, liver cirrhosis).Journal of Ethnopharmacology, 297 (2022) 115550

2. Zecheng Huang, Chunyi Xu, Linxian Zhao, Chunlei Wei, Yuyi Wu, Jing Qiu ,Ziwei Yu, Ke Yang, Huiling Hu*, Zhanguo Wang*.Journal of Drug Delivery Science and Technology, 78 (2022) 103942

3. Ke Yang, Jing Qiu, Zecheng Huang, Ziwei Yu, Wenjun Wang, Huiling Hu* , Yu You **. A comprehensive review of ethnopharmacology, phytochemistry, pharmacology, and pharmacokinetics of Schisandra chinensis (Turcz.) Baill. and Schisandra sphenanthera Rehd. et Wils.Journal of Ethnopharmacology，284 (2022) 114759

4. Yuyi Wu#，Wenjun Wang#, Ziwei Yu, Ke Yang, Zecheng Huang, Ziqiang Chen, Xiaomin Yan, Huiling Hu*, Zhanguo Wang*. Biomaterials Advances, 2022，136：212798

5. Ziqiang Chen, Chunlei Wei, Ziwei Yu, Ke Yang, Zecheng Huang, Huiling Hu*,Zhan-guo Wang*.An effective method for preventing cholestatic liver injury of Aucklandiae Radix and Vladimiriae Radix: Inflammation suppression and regulate the expression of bile acid receptors. Journal of Ethnopharmacology, 294(2022)115330

6. Ziwei Yu, Ziqiang Chen, Qijuan Li, Ke Yang，Zecheng Huang，Wenjun Wang, Siyu Zhao, Huiling Hu*. What dominates the changeable pharmacokinetics of natural sesquiterpene lactones and diterpene lactones: a review focusing on absorption and metabolism. Drug Metabolism Reviews, 2021,53(1):122-140

7. Ziwei Yu, Yu Xie，Ze-Cheng Huang; Ke Yang; Zhan-Guo Wang; Huiling Hu*.Study of the therapeutic effect of raw and processed Vladimiriae Radix on ulcerative colitis based on intestinal flora, metabolomics and tissue distribution analysis. Phytomedicine, 2021 (85), 153538

8. Xiaomin Yan, Zecheng Huang, Yuyi Wu, Ziwei Yu, Ke Yang, Ziqiang Chen, Wenjun Wang, Huiling Hu,*, Zhanguo Wang*. Sequential loading of inclusion complex/nanoparticles improves the gastric retention of Vladimiriae Radix essential oil to promote the protection of acute gastric mucosal injury. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 610 (2021) 121234

9. Zecheng Huang, Chunlei Wei, Ke Yang, Ziwei Yu, Zhanguo Wang, Huiling Hu*. Aucklandiae Radix and Vladimiriae Radix: A systematic review in  ethnopharmacology, phytochemistry and pharmacology. Journal of Ethnopharmacology,2021,114372

10. Wenjun Wang, Qijuan Li, Xiaomin Yan, Ziqiang Chen, Yu Xie, Huiling Hu∗, Zhanguo Wang∗. Comparative study of raw and processed Vladimiriae Radix on pharmacokinetic and anti-acute gastritis effect through anti-oxidation and anti-inflammation. Phytomedicine, 2020, 70:153224

11. Yan Xiaomin, Wang Wenjun, Chen Ziqiang, Xie Yu, Li Qijuan, Yu Ziwei, Hu Huiling*, Wang Zhanguo* . Quality assessment and differentiation of Aucklandiae Radix and Vladimiriae Radix based on GC-MS fingerprint and chemometrics analysis: basis for clinical application. Analytical and Bioanalytical Chemistry, 2020, 412 (7): 1535-1549

12. Ziqiang Chen, Qijuan Li, Ziwei Yu, Xiaomin Yan, Wenjun Wang, Yu Xie, Huiling Hu∗ ,Zhanguo Wang∗.Analysis of the similarities and differences between Auclandia and Vladimirae rhizomes by chemical profiling and chemometric analysis. Journal of Ethnopharmacology, 255 (2020) 112719

13. Qijuan Li, ZhanguoWang, Yu Xie, Huiling Hu∗. Antitumor activity and mechanism of costunolide and dehydrocostus lactone: Two natural sesquiterpene lactones from the Asteraceae family. BIOMEDICINE & PHARMACOTHERAPY, 2020, 125:109955

14. 王文俊，严晓敏，陈自强，李奇娟，谢余，胡慧玲*，王战国*. 木香烃内酯与去氢木香内酯共包封聚乙二醇化长循环脂质体的制备及表征. 中草药，2019，50（17）：4068-4075

15. 胡慧玲,傅超美*,赵萱*,章津铭,高飞,何瑶,傅舒,李玲.中药制剂“毒与效”的整合探析.中国中药杂志,2016,41（18）：3483-3489

16. 胡慧玲（5/8），中药制剂共性技术--制粒关键技术及产业化应用，四川省科技厅，四川省科学技术进步奖，二等奖，2016

17. 《中药药剂学》，编委，中国中医药出版社，2021

18. 《中药药剂学实验双语教材》，副主编，中国医药科技出版社，2020

19. 《中药新药研发学》，编委，中国中医药出版社，2017

20. 《中药提取工艺学》, 编委，人民卫生出版社，2014