一、  个人简介

       2010年博士毕业于四川大学药物化学专业。2013-2016年跟随导师魏于全院士从事博士后研究。2010年7月至今在电子科技大学附属医院·四川省人民医院任职，现为研究员、教授、硕博士研究生导师，美国北卡罗来纳大学教堂山分校访问学者（2016-2018），曾任四川省药物流行病学专委会委员、四川省预防医学会药物应用安全分委会委员、四川省国际医学交流促进会生物免疫治疗专业委员会委员等，现任世界中医药联合会道地药材多维评价理事、中国化学快报青年编委、中国医学生物技术协会纳米生物技术分会委员，被评为第十三批四川省卫生健康委员会学术与技术带头人、第十二批四川省学术与技术带头人后备人选、第十一批省卫生计生委学术技术带头人后备人选。主要从事小分子药物设计与新药开发工作。作为项目负责人，先后承担国家自然基金项目 2 项，中国博士后科研基金面上项目 1 项，国家中医药管理局临床基地建设项目 1 项，四川省自然科学基金创新研究群体项目1项，四川省科技厅杰出青年基金培育项目 1 项，四川省科技厅青年科技创新研究团队项目1项，成都市科技局应用基础项目 1 项，电子科技大学中央高校基金 1 项课题等。近 5 年，申请国家发明专利 9 项，获得 6项国家发明专利授权，在STTT、JMC、CCL、EJMC 等药学权威期刊杂志上发表多篇相关学术论文，其中第一（含并列）作者及通讯作者50余篇。

二、代表性成果（可含承担项目、发表论文、论著、获奖等）

1.科研项目：

1.1 基于计算机辅助设计和SPR发现新颖的SKP2抑制剂及其抗肿瘤活性与机制研究，82073311，在研，56万

1.2 个体化药物治疗小分子创新药物四川省青年科技创新研究团队，2022JDTD0025，在研，40万

1.3 结构新颖的LSD1/GSK3β双靶点小分子抑制剂的设计、合成与抗胃癌药理学研究，2021LY021，在研，30万

1.4 基于智能控制算法神经网络模型研究真空冷冻干燥川芎工艺，2021HX026，在研，10万

1.5 基于计算机辅助的HDAC/Aurora双靶点 抑制剂的设计、合成、活性筛选及机制研究，川干研2022-219，在研，5万

2.发表论文

【1】Lu Haiying, Zhou Qiaodan, He Jun, Jiang Zhongliang, Peng Cheng*, Tong Rongsheng*, Shi Jianyou*, Recent advances in the development of protein-protein interactions modulators: mechanisms and clinical trials [J], Signal Transduction and Targeted Therapy, 5(1), 213, 2020

【2】Peng Ting, Qi Baowen, He Jun, Ke Hengming*, Shi Jianyou*, Advances in the Development of Phosphodiesterase-4 Inhibitors [J], Journal of Medicinal Chemistry, 63(19): 10594-10617, 2020

【3】Qi Baowen, Zhong Ling, He Jun, Zhang Hongjia, Li Fengqiong, Wang Ting, Zou Jing, Lin Yao-Xin, Zhang Chengchen, Guo Xiaoqiang, Li Rui*, Shi Jianyou*, Discovery of Inhibitors of Aurora/PLK Targets as Anticancer Agents [J], Journal of Medicinal Chemistry, 62(17): 7697-7707, 2019

【4】Hou Jun, Jiang Changqing, Wen Xudong, Li Chengming, Xiong Shiqiang, Yue Tian, Long Pan*, Shi Jianyou*, Zhang Zhen*, ACSL4 as a Potential Target and Biomarker for Anticancer: From Molecular Mechanisms to Clinical Therapeutics [J], Frontiers in Pharmacology, 13, 949863, 2022

【5】Liang Qi, Liu Maoyu, Li Jian, Tong Rongsheng, Hu Yonghe*, Bai Lan*, Shi Jianyou*, NAE modulators: A potential therapy for gastric carcinoma [J], European Journal of Medicinal Chemistry, 231, 114156, 2022

【6】Wu Xianbo, Xu Yihua, Liang Qi, Yang Xinwei, Huang Jianli, Wang Jie, Zhang Hong*, Shi Jianyou*, Recent Advances in Dual PI3K/mTOR Inhibitors for Tumour Treatment [J], Frontiers in Pharmacology, 13, 875372, 2022

【7】Xin Ren, Jianyou Shi, Ruihuan Duan, Jun Di, Chao Xue, Xiao Luo, Qing Liu, Mengyang Xia∗, Bo Lin∗, Wu Tang∗, Construction of high-efficiency CoS@Nb2O5 heterojunctions accelerating charge transfer for boosting photocatalytic hydrogen evolution [J], Chinese Chemical Letters, 33, 4700-4704, 2022

【8】Zhang Zhenzhen, Liu Xin, Zhao Liyun, Zhou Yaru, Shi Jianyou*, Chen Weini*, Li Jinqi*, A review on the treatment of multiple myeloma with small molecular agents in the past five years [J], European Journal of Medicinal Chemistry, 229, 114053, 2022

【9】Liang Qi, Wang Juelan, Zhao Liyun, Hou Jun*, Hu Yonghe*, Shi Jianyou*, Recent advances of dual FGFR inhibitors as a novel therapy for cancer [J], European Journal of Medicinal Chemistry, 214, 113205, 2021

【10】Wang Ting, Xu Kaiju, Zhao Liyun, Tong Rongsheng*, Xiong Liang*, Shi Jianyou*, Recent research and development of NDM-1 inhibitors [J], European Journal of Medicinal Chemistry, 223, 113667, 2021

【11】Zhao Jing, Hu Gang, Huang Yi, Huang Yingchun*, Wei Xin*, Shi Jianyou*, Polysaccharide conjugate vaccine: A kind of vaccine with great development potential [J], Chinese Chemical Letters, 32(4): 1331-1340, 2021

【12】Du Xingkai, Li Jian, Luo Xiaojiao, Li Rong, Li Feng, Zhang Yiwen, Shi Jianyou*, He Jun*, Structure-activity relationships of Wee1 inhibitors: A review [J], European Journal of Medicinal Chemistry, 203, 112524, 2020

【13】He Li, Su Qian, Bai Lan, Li Meifeng, Liu Juanru, Liu Xiaomei, Zhang Cunyan, Jiang Zhongliang, He Jun, Shi Jianyou*, Huang Shan*, Guo Li*, Recent research progress on natural small molecule bibenzyls and its derivatives in Dendrobium species [J], European Journal of Medicinal Chemistry, 204, 112530, 2020

【14】Wang Ting, Wang Yujue, Liu Li, Jiang Zhongliang, Li Xingxing, Tong Rongsheng, He Jun*, Shi Jianyou*, Research progress on sirtuins family members and cell senescence [J], European Journal of Medicinal Chemistry, 193, 112207, 2020

【15】Yuan Ting, Qi Baowen, Jiang Zhongliang, Dong Wenjuan, Zhong Lei, Bai Lan, Tong Rongsheng, Yu Jiying*, Shi Jianyou*, Dual FLT3 inhibitors: Against the drug resistance of acute myeloid leukemia in recent decade [J], European Journal of Medicinal Chemistry, 178468-483, 2019

【16】Zhou Yanping, Jiang Zhongliang, Lu Haiying, Xu Zhuyu, Tong Rongsheng, Shi Jianyou*, Jia Guiqing*, Recent Advances of Natural Polyphenols Activators for Keap1-Nrf2 Signaling Pathway [J], Chemistry & Biodiversity, 16(11): 2019

3.获奖

3.1 2020年入选第一批“浣花英才计划”学科骨干项目

3.2 四川省卫生健康委员会第五期委（局）直属单位高层次人才专题研修班优秀学员。