苏海国
一、个人简介
2021年毕业于中国科学院昆明植物研究所,获得药物化学博士学位,同年到中山大学药学院药理系进行博士后研究,现任威尼斯98488特聘副研究员,硕士生导师,入选四川省优秀青年人才项目。主要研究方向为天然产物调控代谢稳态在疾病中的应用及机制,近年来对赤芝、树舌灵芝、黄边灵芝、反柄紫芝、田基黄等中药的药效物质基础进行了系统研究,发现新化合物100余个,探索了它们对于脂质代谢和胆汁酸代谢的影响,在国内外期刊发表论文20余篇,目前主持国家自然科学基金青年项目1项、四川省自然科学基金面上项目1项。担任世中联中药分析专委会理事,广东省药理学会药物代谢专业委员会委员,Chinese Herbal Medicines、Food & Medicine Homology等期刊青年编委,Chemical Communications等期刊常邀审稿人。
Email:suhaiguo@cdutcm.edu.cn
二、代表性成果(可含承担项目、发表论文、论著、获奖等)
【承担课题】
1. 国家自然科学基金青年项目,田基黄中PXR小分子激动剂的发现及其抗胆汁淤积性肝损伤研究,2023.01−2025.12,30万元,主持
2. 威尼斯98488,引进人才科研启动经费,2023.01−2025.12,25万元,主持
【近5年代表性论文】
1. Liu X.J. #; Su, H.G. #; Peng, X. R.; Bi, H.C.*; Qiu, M. H.*, An updated review of the genus Rhododendron since 2010: Traditional uses, phytochemistry, and pharmacology. Phytochemistry 2024, 217, 113899. (中科院2区)
2. Su, H.G.; Liang, H.F.; Hu, G.L.; Zhou, L., Peng, X. R.*; Bi, H.C.*; Qiu, M. H.*, Applanoids A−E as the first examples of C-15/C-20 Michael adducts in Ganoderma triterpenoids and their PXR agonistic activity. Chinese journal of Chemistry, 2022, 40(22), 2633-2641. (Cover Story, 中科院2区)
3. Su, H.-G.#; Wang, Q. #; Zhou, L.; Peng, X.-R.*; Xiong, W.-Y.*; Qiu, M.-H.*, Functional triterpenoids from medicinal fungi Ganoderma applanatum: a continuous search for antiadipogenic agents. Bioorganic Chemistry, 2021,112, 104977.(中科院1区)
4. Peng X.-R.#; Su, H.-G.#; Wang, H.-R.; Hu, G.-L.; Hu, K.; Zhou, L.; Qiu, M.-H.*, Applanmerotic acids A and B, two meroterpenoid dimers with an unprecedented polycyclic skeleton from Ganoderma applanatum that inhibit formyl peptide receptor 2. Organic Chemistry Frontiers, 2021,8(13),3381-3389. (中科院1区)
5. Su, H.-G.#; Wang, Q. #; Zhou, L.; Peng, X.-R.*; Xiong, W.-Y.*; Qiu, M.-H.*, Highly oxygenated lanostane triterpenoids from Ganoderma applanatum as a class of agents for inhibiting lipid accumulation in adipocytes. Bioorganic Chemistry 2020, 104, 104263. (中科院1区)
6. Su, H.-G.; Peng, X.-R.; Shi, Q.-Q.; Huang, Y.-J.; Zhou, L.; Qiu, M.-H.*, Lanostane triterpenoids with anti-inflammatory activities from Ganoderma lucidum. Phytochemistry 2020, 173, 112256. (中科院2区)
7. Su, H.-G.; Zhou, Q.-M.; Guo, L.; Huang, Y.-J.; Peng, C.; Xiong, L.*, Lanostane triterpenoids from Ganoderma luteomarginatum and their cytotoxicity against four human cancer cell lines. Phytochemistry 2018, 156, 89-95. (中科院2区)